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| Professor |
| Office:
919-966-2903 |
| E-mail:
vgodfrey@med.unc.edu |
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| My
interests include veterinary pathology, animal models of disease,
T cell development and biology, and autoimmunine disease. |
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| Castillo A, Morse HC, Godfrey VL, Naeem R, Justice, MJ. 2007. Misexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Research. In press. |
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| Bultman SJ, Herschkowitz JI, Godfrey V, Gebuhr TC, Yaniv M, Perou CM, Magnuson T. 2007. Characterization of mammary tumors in Brg1 heterozygous mice. Oncogene. Jul 16 [Epub ahead of print]. |
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| Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Yan, Wang Y, Liu X, Chan M, Liu J-Q, Love R, Liu C-g, Godfrey V, Shen R, Huang T, Yang T, Park B, Wang C-Y, Zheng P, Liu Yang. 2007. FOXP3 is an X-linked breast suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell. Jun 29; 129(7): 1275-86. |
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| Chai J, Lu X, Godfrey V, Fletcher C, Roberts CW, Van Dyke T, Weissman BE. 2007. Tumor-specific cooperation of retinoblastoma family and Snf5 inactivation. Cancer Res. Apr.1: 67(7): 3002-9. |
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| Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V, Koller BH. 2006. Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice. Mol. Cell Biol. 26(24): 9571. |
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| Chang X, Chen L, Jing W, Godfrey VL, Qiao G, Hussien Y, Zhang J, Gao JX 2006. Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Clin. Immunol. 121(3): 274-285. |
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| Garcia-Contreras L, Sethuraman V, Kazantseva M, Godfrey V, Hickey AJ. 2006. Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. J. Antimicrobial Chemotherapy. 58: 980-986. The Mouse in Biomedical Research, Second Edition, Volume 2: Diseases. Elsevier Inc. San Diego, CA. Eds. James G. Fox, Christian Newcomer, Abigail Smith, Stephen Barthold, Fred Quimby, Muriel Davisson. Chapter 20: Fungal diseases in laboratory mice, pp. 507-514. 2007. |
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| Bissahoyo
A, Pearsall RS, Hanlon K, Amann V, Hicks D, Godfrey VL, Threadgill
DW. 2005. Azoxymethane is a genetic background-dependent
colorectal tumor initiator and promotor in mice: effects
of dose, route, and diet. Toxicol. Sci. 88(2): 340-5. |
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| Chang X, Gao JX, Jiang Q, Wen J, Seifers N, Su L, Godfrey
VL, Zuo T, Zheng P, Liu Y. 2005. The scurfy mutation of foxp3
in the thymic stroma lead to defective thymopoieisis and over-expression
of the erbB2 gene. J. Exp. Med. 202(8): 1141-51. |
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| Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D,
Schlossmann J, Schiemann M, Hofmann F, Pryzwansky KB. 2005.
Neutrophil dysfunction in guanosine 3’, 5’-cyclic
monophosphate-dependent protein kinase I – deficient
mice. J. Immunol. 175:1919–1929. |
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| Gebuhr TC, Kovalev GI, Bultman S, Godfrey V, Su L, Magnuson
T. 2003. The role of Brg 1, a catalytic subunit of mammalian
chromatin- remodeling complexes, in T cell development. J Exp
Med 198(12):1937-49. |
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| Dai Q, Zhang C, Wu Y, McDonough H, Whaley R, Godfrey V, Li
H-H, Madamanchi N, Xu W, Neckers L, Cyr D, Patterson C. 2003.
CHIP activates HSF1 and confers protection against apoptosis
and cellular stress. EMBO J. 22(20): 1-13. |
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| Boivin GP, Washington K, Yang K, Ward J, Pretlow TP, Russell
R, Besselsen DG, Godfrey VL, Doetschman T, Groden J, Halberg
RB, Itzkowitz SH, Coffey RJ. 2003. Pathology of mouse models
of intestinal cancer: Consensus report and recommendations.
Gastroenterology. 124(3): 762-777. |
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| Bai F , Pei X-H , Godfrey VL, Xiong Y. 2003. Haploinsufficiency
of p18INK4c sensitizes mice to carcinogen-induced tumorigenesis
. Mole. Cell. Biol. 23(4): 1269-1277. |
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| Southern KW, Funkhouser WK, Kazachkova I, Godfrey VL, Fordham
LA, Gatzy JT, Barker PM. 2002. Airway surface liquid recovered
by lavage with perfluorocarbon liquid in cats. Eur. J Clin.
Invest. 32(12): 956-61. |
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| Backlund MG. Trasti SL. Backlund DC. Cressman VL. Godfrey
V. Koller BH. 2001. Impact of ionizing radiation and genetic
background on mammary tumorigenesis in p53-deficient mice.
Cancer Research. 61(17):6577-82. |
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| Franklin DS, Godfrey VL, O’Brien DA, Deng C, Xiong Y.
2000. Functional collaboration between differnent cyclin-dependent
kinase inhibitors suppresses tumor growth with distinct tissue
specificities. Mole. Cell. Biol. 20 (16): 6147-6158. |
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| Makris C, Godfrey VL, Krahn-Senftleben G, Takahashi T, Roberts
JL, Schwatz, T, Fene L, Johnson RS, Karin M. 2000. Female mice
heterozygous for IKK?/NEMO deficiencies develop a dermatopathy
similar to human X-linked disorder Incontinentia Pigmenti.
Molecular Cell, 5(6): 969-979. |
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| Nishimura T, Nishimura T, deSerres S, Godfrey V, Bradham CA,
Nakagawa T, Brenner DA, Meyer AA. 2000. Gene expression and
cytomkine and enzyme activation in the liver after a burn injury.
J. of Burn Care & Rehabilitation, 21(2): 135-141. |
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| Cressman VL, Backlund DC, Arutskaya AV, Leadon SA, Godfrey
V, and BH Koller. 1999. Growth retardation, DNA repair defects,
and lack of spermatogenesis in BRCA-1 deficient mice. Molecular & Cellular
Biology. 19(10): 7061-7075. |
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| Schultz M, Tonkonogy SL, Sellon RK, Velkamp C, Godfrey VL,
Grenther WB, Balish E, Horak I, Sartor RB. 1999. Interleukin-2
deficient mice raised under germfree conditions develop delayed
mild focal intestinal inflammation. American Journal of Physiology.
276(6 Pt.1), G1461-1472. |
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| Cressman VL, Backlund DC, Hicks EM, Gowen LC, Godfrey V, Koller
BH. 1999. Mammary tumor formation in p53- and BRCA1-deficient
mice. Cell Growth and Differentiation. 10, 1-10. |
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| Kulwichit W, Hood RE, Davenport EM, Baskar JF, Godfrey V,
Raab-Traub N. 1998. Expression of the Epstein-Barr virus latent
membrane protein 1 induces B cell lymphoma in transgenic mice.
PNAS. 95, 11963-11968. |
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| Franklin DS, Godfrey VL, Lee H, Kovalev GI, O’Brien
DA, Schoonhoven R, Chen-Kiang S, Su L, Xiong Y. 1998. CDK Inhibitors
p18INK4c and p27Kip1 mediate two separate pathways to collaboratively
suppress pituitary tumorigenesis. Genes and Development . 12,
2899-2911. |
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| Weintraub JP, Godfrey V, Wolthusen PA, Cheek RL, Eisenberg
RA, Cohen. PL 1997. Immunological and pathological consequences
of mutations in both Fas and Fas ligand. Cellular Immunology.
186(1), 8-17. |
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| Potter MD, Shinpock SG, Popp RA, Godfrey V, Carpenter DA,
Bernstein A, Johnson DK, Rinchik EM. 1997 Mutations in the
murine fitness 1 gene result in defective hematopoiesis. Blood.
90(5), 1850-1857. |
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| Kanangat S, Blair P, Reddy R, Deheshia M, Godfrey V, Rouse
B, Wilkinson E. 1996. Disease in the scurfy (sf) mouse is associated
with overexpression of cytokine genes. European Journal of
Immunology. 26(1), 161-165. |
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| Dees C, Godfrey VL, Schultz RD, Travis CC. 1996. Wild-type
p53 reduces the size of tumors caused by bovine leukemia virus-infected
cells. Cancer Letters. 101(1), 115-122. |
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| Banks TA, Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin
NA, Bouley DM, Thomas J, Kanangat S, Mucenski MM. 1995. Lymphotoxin
-?-deficient mice: Effects on secondary lymphoid organ development
and humoral responsiveness. J. Immunol. 155(4), 1685-93. |
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| Derry JMJ, Wiedeman P, Blair PJ, Wang Y, Kearns JA, Lemahieu
V, Godfrey VL, Wilkinson JE, Francke U. 1995. The murine homolog
of the Wiskott-Aldrich syndrome protein (WASP) gene is highly
conserved and maps near scurfy (sf) on the mouse X chromosome.
Genomics. 29, 471-477. |
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| Niemialtowski MG, Godfrey VL, Rouse BT. 1994. Quantitative
studies on CD4+ and CD8+ cytotoxic T lymphocyte responses against
herpes simplex virus type 1 in normal and beta 2-microglobulin
deficient mice. Immunobiology. 190(3), 183-194. |
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| Dees C, Godfrey VL, Foster JS, Schultz RD, Travis CC. 1994.
Stabilization of the p53 gene product in two bovine leukemia
virus - infected cell lines. Cancer Letters. 86, 33-40. |
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| Blair PJ, Carpenter DA, Godfrey VL, Russell LB, Wilkinson
JE, Rinchik EM. 1994. The mouse scurfy (sf) mutation is tightly
linked to Gata-1 and Tfe-3 on the proximal X chromosome. Mamm.
Genome. 5, 652-654. |
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| Blair PJ, Wilkinson JE, Rouse B, Godfrey VL. 1994. CD4 T cells
are the critical mediators of disease in the scurfy mouse.
J. Immunol. 153, 3764-3774. |
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| Moyer JH, Lee-Tischler MJ, Kwon H-Y, Schrick J, Avner ED,
Sweeney WE, Godfrey VL, Cacheiro NLA, Wilkinson JE, Woychik
RP. 1994. Candidate gene associated with a mutation causing
recessive polycystic kidney disease in mice. Science. 264,
1329-1333. |
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| Godfrey VL, Rouse BT, Wilkinson JE. 1994. Transplantation
of T cell-mediated, lymphoreticular disease from the scurfy
(sf) mouse. Amer. J. Pathol. 145 (2), 218-286. |
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| Selkirk JK, Hite MC, Godfrey V, Merrick BA, He C, Griesemer
RA, Daluge DR, Mansfield BK. 1992. Two-dimensional polyacrylamide
gel electrophorectic characterization of proteins from the
organs of C3H mice expressing the scurfy (sf) mutation during
early and late stages of disease progression. Applied and Theoretical
Electrophoresis 3, 97-107. |
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| Kennel SJ, Godfrey VL, Ch'ang LY, Lankford TK, Foote LJ,
Makkinje A. 1992. The b4 subunit of the integrin family is
displayed on a restricted subset of endothelium in mice. J.
Cell Sci. 101, 145-150. |
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| Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB. 1991. Fatal
lymphoreticular disease in the scurfy (sf) mouse requires T
cells that mature in a sf thymic environment. Proc. Natl. Acad.
Sci. (USA) 88, 5528-5532. |
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| Godfrey VL, Wilkinson JE, Russell LB. 1991. X-linked lymphoreticular
disease in the scurfy (sf) mutant mouse. Am. J. Pathol, 138(6),
1379-1387. |
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| Riond JL, Cullen JM, Godfrey VL, Hunt EL, Anderson KL. 1990.
Bovine viral diarrhea virus-induced cerebellar disease in a
calf. J Am Vet Med Assoc. 197(12): 1631-2. |
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