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| Associate Professor |
| Office:
919-966-3539 |
| E-mail:
hyungsuk_kim@med.unc.edu |
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| My current interests include homeostatic regulation in hypertension and cardiac hypertrophy. To test human system in mice, we have generated animal models by using gene targeting of gene-knockout, gene duplication, 3’UTR or 5’UTR replacements. Decreased or increased protein levels by changed gene expression are valuable phenotypes for studying development of disease states. |
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| Pandya K, Kim H.S., Smithies O. Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression durin cardiac hypertrophy and normal aging in vivo. Proc Natl. Acad. Sci. USA 103: 16864-16869 (2006). |
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| Lee, G., Makhanova, N., Caron, K., Lopez, M.L.S., Gomez, R.A., Smithies, O. and Kim, H.S. Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinol.146: 2650-2656 (2005). |
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| Kakoki, M., Tsai, Y-S., Kim, H.S., Hatada, S., Ciavatta, D.J., Takahashi, N., Arnold, L.W., Maeda, N. and Smithies, O. Altering the expression in mice of genes by modifying their 3’ regions. Developmental Cell, 6: 597-606 (2004). |
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| Kim, H.S., Lee, G., John, S.W.M., Maeda, N. and Smithies, O. Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration. Proc. Natl. Acad. Sci.USA, 99: 4602-4607(2002). |
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| Kim, H.S., Maeda, N., Oh, G.T., Fernandez, L.G., Gomez, R.A. and Smithies, O. Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J. Biol. Chem. 274: 14210-14217 (1999). |
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| Kim, H.S., Krege, J.H., Kluckman, K.D., Hagaman, J.R., Hodgin, J.B., Best, C.F., Jennett, J.C., Coffman, T.M., Maeda, N. and Smithies, O. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. USA 92: 2735-2739 (1995). |
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| Smithies, O. and Kim, H.S. Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc. Natl. Acad. Sci. USA 91: 3612-3615 (1994). |
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| Kim, H.S. and Smithies, O. Recombinant fragment assay for gene targeting based on the polymerase chain reaction. Nucleic Acids Res. 16: 8887-8903 (1988). |
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