| Smithies
O and Kim H-S. Targeted gene duplication and disruption for
analyzing quantitative genetic traits in mice. Proc Natl Acad
Sci USA 91:3612-3615, 1994.
Kim H-S, Krege JH, Kluckman KD, Hagaman JH, Hodgin JB, Best
CF, Jennette JC, Coffman TM, Maeda N and Smithies O. Genetic
control of blood pressure and the angiothensiogen locus.
Proc Natl Acad Sci 92:2735-2739, 1995.
Tsuda H, Maynard-Currie CE, Reid LH, Yoshida T, Edamura
K, Maeda N, Smithies O, Jakobovits A. Inactivation of the
mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb
gene-targeted deletion: Establishment of new HPRT-deficient
mouse embryonic stem cell lines. Genomics 1997;42:413-421.
Smithies O. A mouse view of hypertension. Hypertension 1997;30:1318-1324.
Morham SG, Langenback R, Mohler J, Smithies O. Characterization
of prostaglandin H synthase 2 deficient mice and implications
for mechanisms of NSAID action in eicosanoids and other bioactive
lipids. In: Cancer Inflammation and Radiation Injury (3).
Honn et al (eds). New York: Plenum Press 1997.
Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O,
Ley K, Maeda N. Severe reduction in leukocyte adhesion and
monocyte extravasation in mice deficient in CC chemokine
receptor 2. Proc Natl Acad Sci USA 1997;94:12053-12058.
Oliver PM, Fox JE, Kim R, Rockman HA, Kim H-S, Reddick RL,
Pandey KN, Milgram SL, Smithies O, Maeda N. Hypertension,
cardiac hypertrophy, and sudden death in mice lacking natriuretic
peptide receptor A. Proc Natl Acad Sci USA 1997;94:14730-14735.
Oliver PM, John SWM, Purdy KE, Kim R, Maeda N, Goy MF, Smithies
O. Natriuretic peptide receptor 1 expression influences blood
pressures of mice in a dose-dependent manner. Proc Natl Acad
Sci USA 1998;95:2547-2551.
Hagaman JR, Moyer JS, Bachman ES, Sibony M, Magyar PL, Welch
JE, Smithies O, Krege JH, O’Brien DA. Angiotensin-converting
enzyme and male fertility. Proc Natl Acad Sci USA 1998;95:2552-2557.
Lewis J, Yang B, Kim R, Sierakowska H, Kole R, Smithies
O, Maeda N. A common human ß globin splicing mutation
modeled in mice. Blood 1998;91(6):2152-2156.
Whitney III JB, Leder A, Lewis J, Popp RA, Paszty C, Rubin
EM, Shehee WR, Townes TM, Smithies O. Rapid genotyping of
mice with hemoglobinopathies and globin transgenes. Biochem
Genet 1998;36:65-77.
Tumpey TM, Cheng H, Cook DN, Smithies O, Oakes JE, Lausch
RN. Absence of macrophage inflammatory protein-1? prevents
the development of blinding herpes stromal keratitis. J Virol
1998;72:3705-3710.
Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, Hiller
S, Kluckman K, Maeda N, Smithies O, Coffman TM. Reduced growth,
abnormal kidney structure, and AT2-mediated blood pressure
in mice lacking both AT1A and AT1B receptors for angiotensin
II. Proc Natl Acad Sci USA 1998;95:15496-15501.
Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler
JF, Sar M, Korach KS, Gustafsson JA, Smithies O. Generation
and reproductive phenotypes of mice lacking estrogen receptor-?.
Proc Natl Acad Sci USA 1998;95:15677-15682.
Thomas DW, Mannon RB, Mannon PJ, Latour A, Oliver PA, Hoffman
M, Smithies O, Koller BH, Coffman TM. Coagulation defects
and altered hemodynamic responses in mice lacking receptors
for thromboxane A2. J Clin Invest 1998;102:1994-2001.
Fern RJ, Yesko CM, Thornhill BA, Kim HS, Smithies O, Chevalier
RL. Reduced angiotensinogen expression attenuates renal interstitial
fibrosis in obstructive nephropathy in mice. J Clin Invest
1999;103:39-46.
Kim HS, Maeda N, Oh GT, Fernandez LG, Gomez RA, Smithies
O. Homeostasis in mice with genetically decreased angiotensinogen
is primarily by an increased number of renin-producing cells.
J Biol Chem 1999;274 (In press).
Hatada S, Kuziel W, Smithies O, Maeda N. The influence of
chromosomal location on the expression of two transgenes
in mice. J Biol Chem 1999;274:948-955.
Pandey KN, Oliver PM, Maeda N, Smithies O. Regulation of
serum testosterone levels by the natriuretic peptide receptor-A
in gene-knockout and gene-duplicated mutant mouse models.
Submitted to Endocrinology 1999.
Maeda N, Smithies O. Studying the genetics of complex but
common human diseases using mice. In press. |