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| Assistant Professor |
| Office:
919-966-2421 |
| E-mail: hongx@med.unc.edu |
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| My
research interests are around immune-mediated glomerular diseases
and vasculitis. My current studies focus on defining the immunopathological
mechanisms involved in autoimmune glomerulonephritis and vasculitis
with particular emphasis on understanding the role of anti-neutrophil
cytoplasmic autoantibodies (MPO-ANCA and Pr3-ANCA) in the pathogenesis
of glomerular/vascular injury. In the past years, I generated
a MPO-ANCA disease mouse model that facilitated the studies
of the mechanisms of the ANCA disease. By using this mouse
model, I have studied the role of inflammatory cells, cytokines
and complements in the pathogenesis of ANCA disease. Recently
I have been working on developing a Pr3-ANCA mouse disease
model as well. My goal aims to find out potential targets for
therapeutic intervention of ANCA glomerulonephritis and vasculitis. |
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| Huugen D, van Esch A, Xiao H, Peutz-kootstra CJ, Buuman WA, Tervaert JW, Jennette JC, Herringa P.Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int. 2007 Apr; 71(7):646-54. |
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| Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies. Am J Pathol January 2007, Vol. 170 (1): 52-64. |
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| Schreiber A, Xiao H, Falk RJ, Jennette JC. Bone Marrow-Derived Cells Are Sufficient and Necessary Targets to Mediate Glomerulonephritis and Vasculitis Induced by Anti-Myeloperoxidase Antibodies. J Am Soc Nephrol 2006 Dec; 17 (12): 3355-64. |
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| Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 2006 May, 17(5):1235-42. |
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| Xiao
H, Heeringa P, Liu Z, Huugen D, Hu P, Falk RJ, Jennette JC:
A major role for neutrophils in anti-myeloperoxidase antibody
induced necrotizing and crescentic glomerulonephritis. Am
J Pathol 167:39-45, 2005. |
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| Huugen D, Xiao H, Jennette JC, Heeringa P: Aggravation of
anti-myeloperoxidase antibody induced glomerulonephritis
by bacterial lipopolysaccharide: role of tumor necrosis factor
a. Am J Pathol 167:47-58, 2005. |
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| Xiao H, Heringa Peter, Hu P, Liu Z, Zhao M, Aratani Y, Maeda
NN, Falk RJ, Jennette JC. Antineutrophil Cytoplasmic Autoantibodies
Specific for Myeloperoxidase Cause Glomerulonephritis and Vesculitis
in Mice. J Clin Invest 2002; 110:955-963. |
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| Preston
GA, Yang JJ, Xiao H, Falk RJ. Understanding the pathogenesis
of ANCA: where are we today? Cleve Clin J Med 2002; 69 Suppl
2:SII51-4. |
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