Charlotte A. Lanteri Department of Pathology & Laboratory Medicine School of Medicine Expected Graduation Date: May 2004 Project Name: Trypanosomal Transport and Mitochondrial Effects of 2,5-bis(4-amidinophenyl)furan (DB-75) Description: Investigations into the mechanisms of transport and trypanocidal action of DB-75 involving uptake by the P2 amino-purine transporter and other trypanosome-specific plasma membrane proteins as well as changes in mitochondrial membrane potential relating to trypanocidal activity.
	Lisa M. Nelson Department of Pathology & Laboratory Medicine School of Medicine Expected Graduation Date: May, 2004 Project Name: Chemical Pathogenesis of Cerebral Sleeping Sickness Description: Studies will focus on the effect of acute and chronic infection on blood-brain barrier permeability, the effect of inflammatory molecule expression on parasite survival, host cellular disruption, progression of disease, and prognostic ability for treatment efficacy.
	Janelle Y. Saulter Department of Medicinal Chemistry School of Pharmacy Expected Graduation Date: May, 2005 Project Name: Transport and Metabolism of New Potential Antimicrobial Prodrugs for 2,5-bis(4-amidinophenyl)furan (DB-75) Description: Goals include the investigation of mechanisms of oral transport and bioactivation of several metabolites of the prodrug DB-289 via their ability to cross the epithelial barrier, along with studies of the major enzymes involved in the biotransformation.