Recent Publications
- Brendle, J.J., A. Outlaw, A. Kumar, D.W. Boykin, D.A. Patrick, R.R. Tidwell, and K.A. Werbovetz. Antileishmanial activities of several classes of aromatic dications. Antimicrob. Agents Chemother. 46:797-807., 2002.
- Pereira, A.S., K.B. Kenney, M.S. Cohen, J.J. Eron, R.R. Tidwell, and J.A. Dunn. Determination of amprenavir, a HIV-1 protease inhibitor, in human seminal plasma using high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Biomed. Sci. Appl. 766:307-17., 2002.
- Pereira, A.S. and R.R. Tidwell. Separation methods for nucleoside analogues used for treatment of HIV-1 infection. J. Chromatogr. B Biomed. Sci. Appl. 764:327-47., 2001.
- Tanious, F.A., W.D. Wilson, D.A. Patrick, R.R. Tidwell, P. Colson, C. Houssier, C. Tardy, and C. Bailly. Sequence-dependent binding of bis-amidine carbazole dications to DNA. Eur. J. Biochem. 268:3455-64., 2001.
- Patrick, D.A., J.E. Hall, B.C. Bender, D.R. McCurdy, W.D. Wilson, F.A. Tanious, S. Saha, and R.R. Tidwell. Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs. Eur. J. Med. Chem. 34:575-83., 1999.
- Tanious, F.A., Ding, D., Patrick, D.A., Bailly, C., Tidwell, R.R., and Wilson, W.D. Effects of compound structure on carbazole dication-DNA complexes: tests of the monor-groove complex models. Biochemistry 39(39):12091-101, 2000 .
- Pereira, A.S., Kenney, K.B., Cohen, M.S., Hall, J.E., Eron, J.J., Tidwell, R.R., and Dunn, J.A. Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry. J. Chromatogr. B Biomed. Sci. Appl. 742(1):173-83, 2000.
- Reisner, H.M., Gray, D.R., Jones, S.K., Rose, B.G., and Tidwell, R.R. Immunoassays for pentamidine and related compounds: development of a facile inhibitory ELISA suitable for clinical use. J. Clin. Lab. Anal. 14(2):73-82, 2000.
- Pereira, A.S., Kashuba, A.D., Fiscus, S.A., Hall, J.E., Tidwell, R.R., Troiani, L., Dunn, J.A., Eron, J.J. Jr, Cohen, M.S. Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden. J. Infect. Dis. 180(6):2039-43,1999.
- Wood, D.H., Hall, J.E., Rose, B.G., Boykin, D.W., and Tidwell, R.R. Pentamidine is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 receptors. Ann. NY Acad. Sci. 881:110-3, 1999.
- Hall, J.E., Kerrigan, J.E., Ramachandran, K., Bender, B.C., Stanko, J.P., Jones, S.K., and Tidwell, R.R. Anti-pneumocystis activity of aromatic diamidoxime prodrugs. Antimicrob. Agents and Chemother. 42:666-674, 1998.
- Wood, D.H., Hall, J.E., Rose, B.G., and Tidwell, R.R. 1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 binding sites. Eur. J. Pharmacol., 353:97-103, 1998.
- Boykin, D.W., Kumar, A., Xiao, G., Wilson, W.D., Bender, B.C., McCurdy, D.R., Hall, J.E. and Tidwell, R.R. 2,5-Bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. J. Med. Chem. 41:124-129, 1998.
- Hildebrandt, E.F., Boykin, D.W., Tidwell, R.R., Dykstra, C.C. Identification and characterization of an endo/exonuclease in Pneumocystis carinii that is inhibited by dicationic diaryl furans with efficacy against pneumocystis pneumonia. J. Euk. Microb. 45:112-121, 1998.
- Del Poeta, M., Schell, W.A., Dykstra, C.C., Jones, S.K., Tidwell, R.R., Czarny, A., Bajic, M., Bajic, M., Kumar, A., Boykin, D., and Perfect, J.R. Structure-in vitro activity relationships of pentamidine analogues and dicationic substituted bis-benzimidazoles as new antifungal agents. Antimicrob. Agents Chemother., 42:2495-2502, 1998.
- Blagburn, B.L., Drain, K.L., Land, T.M., Kinard, R.G., Moore, P.H, Lindsay, D.S., Patrick, D.A., Boykin, D.W., and Tidwell, R.R. Comparative efficacy evaluation of dicationic carbazole compounds, itazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model. Antimicrob. Agents Chemother., 42:2877-2882, 1998.
- Tanious, F., Ding, D., Patrick, D.A., Tidwell, R.R., and Wilson, W.D. A new type of DNA minor-groove complex: Carbazole dication - DNA interactions, activity. Biochem. 36:15315-15325, 1997.