Monte S. Willis, M.D., Ph.D.

Monte S. Willis, M.D., Ph.D.
Assistant Professor, University of North Carolina at Chapel Hill
Director, Sweat Chloride Testing, UNC Hospitals
Assistant Director, Clinical Core (Chemistry) Laboratory, UNC Hospitals
M.D./Ph.D. University of Nebraska, 2001
Resident, Clinical Pathology, University of Texas Southwestern 2001-2004
Post-Doctoral Fellow, University of Texas Southwestern 2002-2004
Resident, Post-Doc. Fellow, Clinical Pathology, University of North Carolina, 2004-2005

 

 

Potential Medical and Graduate Student Research Projects (.doc)

Curriculum Vitae (.doc)

Pathology 723 2008 Course Schedule (.doc)

 

Selected Publications:

Original Basic Science Research (of 29 total)

1.   Garner LB & Willis MS (Co-first author), Carlson DL, DiMiao JM, White MD, White DJ, Adams GA, Horton
      JW, Giroir BP: Macrophage migration inhibitory factor (MIF) is a cardiac-derived myocardial depressant
      factor. Am J Physiol Heart Circ Physiol, 2003; 285(6):H2500-9.

2.   Willis MS, Carlson DL, DiMiao JM, White MD, White DJ, Adams, GA, Horton JW, Giroir BP: Macrophage
      migration inhibitory factor (MIF) mediates late cardiac dysfunction following burn injury. Am J Physiol Heart
      Circ Physiol, 2005; 288(2):H795-804.

3.   Binck BW, Tsen MF, Islas M, White J, Schultz RA, Willis MS, Garcia JV, Horton JW, Thomas JA: Bone
      marrow-derived cells contribute to contractile dysfunction in endotoxic shock. Am J Physiol Heart Circ
      Physiol, 2005; 288(2):H577-83.

4.   Carlson DL, Willis MS, White DJ, Horton JW, Giroir BP. Tumor necrosis factor-alpha-induced caspase
      activation mediates endotoxin-related cardiac dysfunction. Crit Care Med, 2005; 33(5):1021-8.

5.   Ramana KV, Willis MS, White MD, Horton JW, Dimaio JM, Srivastava D, Bhatnagar A, Srivastava SK:
      Endotoxin-Induced Cardiomyopathy and Systemic Inflammation in Mice Is Prevented by Aldose Reductase
      Inhibition. Circulation. 2006; 114(17):1838-46.

6.   Willis MS, Ike C, Li L, Wang DZ, Glass DJ, Patterson C: MuRF1, but not MuRF2, Regulates Cardiac
      Hypertrophy In Vivo. Circ Res. 2007; 100(4):456-9.

7.   Stansfield WE, Rojas M, Corn D, Willis M, Patterson C, Smyth SS, Selzman CH: Characterization of a
      novel model to independently study regression of ventricular hypertrophy. J Surg Res, 2007; 142(2):387-93.

8.   Stansfield WE, Tang R, Moss NC, Willis MS, Selzman CH: Proteasome inhibition promotes regression of
      left ventricular hypertrophy. Am J Physiol Heart Circ Physiol., 2007; in press.

9.   Stansfield WE, Moss NC, Willis MS, Tang R, Selzman CH: Proteasome inhibition attenuates infarct size
      and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury. Ann Thorac
      Surg. 2007; 84(1):120-5.

10. Moss NC, Stansfield WE, Willis MS, Tang R, Selzman CH: Inhibitory Kappa Kinase Beta (IKKβ) Inhibition Attenuates Myocardial Injury and Dysfunction Following Acute Ischemia-Reperfusion Injury.  Am J Physiol Heart Circ Physiol. 2007;293(4):H2248-53.

11. Clarke BA, Drujan D, Willis MS, Murphy LO, Corpina RA, Burova E, Rakhilin SV, Stitt TN, Patterson C, Latres E, Glass DJ: The E3 ligase MuRF1 degrades Myosin Heavy Chain protein in Dexamethasone treated skeletal muscle.  Cell Metab. 2007; 6(5):376-85.

12. Li H & Willis MS (Co-First Author), Lockyer P, Miller N, McDonough H, Patterson C: Atrogin-1/Muscle atrophy F-box inhibits Akt-dependent cardiac hypertrophy via atypical ubiquitylation and co-activation of Forkhead proteins.  J Clin Invest. 2007;117(11):3211-3223.

 

Original Clinical Science

13. Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, Bhushan V, Kroft SH:
Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination.
Am J Clin Pathol, 2005; 123:125-31.

14. Willis MS, McKenna RW, Peterson LC, Coad JE, Kroft SH: Low blast count myeloid disorders with auer
rods: a clinicopathologic analysis of 9 cases. Am J Clin Pathol, 2005; 124(2): 191-198.

15. Church TS, Willis MS, Priest EL, LaMonte MJ, Earnest CP, Wilkinson WJ, Wilson DA, Giroir BP: Obesity,
macrophage migration inhibitory factor, and weight loss. Int J Obesity, 2005; 29(6):675-81.

16. Willis MS, Lee ES, Grenache DG: Effect of anemia on plasma concentrations of NT-proBNP. Clin Chim
Acta, 2005; 358(1-2):175-81.

17. Snyder JA, Willis MS, and Grenache DG: Immunofixation reveals an apparent alpha heavy chain caused
by precipitation of fibrinogen with IgA antisera. Clin Chim Acta, 2006, 368(1-2):192-4.

18. Willis MS, Snyder JA, Poppenga RH, Grenache DG: Bovine cardiac troponin T is not accurately quantified
with a common human clinical immunoassay. J Vet Diagn Invest, 2007, 19(1): 106-8.

19. Afenyi-Annan A, Willis MS, Konrad TR, Lottenberg R: Blood bank management of sickle cell patients at comprehensive sickle cell centers. Transfusion, 2007, 47(11):2089-2097.

20. McCudden CR, Mathews SP, Hainsworth SA, Chapman JF, Hammett-Stabler CA, Willis MS, Grenache DG: Performance comparison of capillary and agarose gel electrophoresis for the identification and characterization of monoclonal immunoglobulins. Am J Clin Pathol, 2007, in press.

 

Review Manuscripts (of 11 total)

21. Willis MS, Patterson C: Into the Heart: The Emerging Role of the Ubiquitin-Proteasome System. J Mol
      Cell Cardiol. 2006; 41(4):567-79.

22. Patterson C, Ike C, Willis PW, Stouffer GA, Willis MS: The bitter end: The ubiquitin-proteasome system
      and heart failure. Circulation, 2007; 115(11):1456-63.

23. Willis MS, Schisler JC, Patterson C: Appetite for Destruction: E3 Ubiquitin-Ligase Protection in Cardiac
      Disease. Future Cardiology, 2008, in press.

24. Schisler JC, Willis MS, Patterson C: You Spin Me Round: Atrogin-1 Feeds Forward on FOXO Transcription Factors (Like a Record).  Cell Cycle, 2008, in press.

 

Non-Experimental Case Studies (of 28 total)

25. Roth M, Aitsebaomo, and Willis MS: Chest Pain, Dyspnea, and Fatigue in a 57 Year-Old Man (Cardiac
      Amyloidosis Case Study and Review). Lab Med, 2007; 38(9): 543-548.

26. McCudden CR, Willis MS, Grenache DG: Persistent low concentration of human chorionic gonadotropin
      In a non-pregnant female. Clin Chem, 2007, in press.

27. Pierce K, Willis MS, McCudden CR: Primary Hyperparathyroidism. Lab Med, 2007, in press.

 

Selected Recent Abstracts

28. Willis MS, Rojas M, Li L, Ike C, Patterson C.  Muscle Ring Finger-1 (MuRF1) Expression is Essential for the   Reversal of Cardiac Hypertrophy In Vivo.  Circulation 2007; 116(16):II-258.

29. Willis MS, Ren R, Patterson C. Bmper (BMP-binding Endothelial cell precursor-derived Regulator) is Critical to Cardiac Muscle Mass Regulation during Development and Pressure Overload Induced Hypertrophy.  Circulation 2007; 116(16):II-253.

30. Willis MS, Schisler JC, McDonough H, Patterson C.  Muscle Ring Finger-1 (MuRF1) Expression Shifts  Cardiomyocyte Substrate Utilization from Fatty Acids to Glucose.  Circulation 2007; 116(16):II-120.

31. Willis MS, Rojas M, Lockyer P, Meredith D, Hampton TG, Li L, Patterson C.  Cardiac Specific Muscle Ring Finger-1 (MuRF1) Protects Against Ischemia/Reperfusion Injury In Vivo.  Circulation 2007; 116(16):II-200.

32. Ren R, Willis MS, McDonough H, Kelley R, Wu Y, Patterson C.  Deletion Of Bmper In Mice Identifies A Novel Bmp-dependent Pathway For Regulating Cardiomyocyte Hypertrophy. Circulation 2007; 116(16):II-49.