Chih-Hong Wang
B.S., Medical Technology
China Medical University
Taichung, Taiwan
M.S., Biochemistry
National Chung-Hsing University
Taichung, Taiwan
I was born and raised in a beautiful country - Taiwan.  There are a lots delicious foods and wonderful beaches.  I received my B.S. in medical technology from China Medical University and M.S. in biochemistry from National Chung-Hsing University and then I spent a couple of years working in biocompany in transgenic animals and DNA microarry.  In 2004, I came to UNC and worked with Dr. Darrel W. Stafford to study in Vitamin K epoxide reductase (VKOR) and coagulation factors.  According to my interests and my experience- mouse model, I made a decision to join the Molecular and Cellular Pathology Program and work with Dr. Nobuyuki Takahashi who is an expert in Diabetic Nephropathy. 

My current project aims to understand the mechanism of Diabetic Nephropathy (DN) and its therapeutic strategies to treat it.  DN is an End-Stage Renal Disease (ESRD), which occurs in 30% of type I and type II diabetics in U.S.  Several studies have suggested that an endothelial Nitric Oxide Synthase (eNOS) polymorphism is associated with DN.  However, its mechanism remains unclear.  To investigate this mechanism, we use eNOS knockout mice (eNOS-/-) to inject STZ to explore how eNOS polymorphism exacerbates DN.  Meanwhile, we also used anticoagulants and AGE inhibitors to treat eNOS-/- diabetic mice and investigate whether DN can be ameliorated.  We ultimately aim to find the mechanism of DN in diabetics and how to ameliorate it. 
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