|
B.S., Chemistry M.S., Biochemistry American University Beirut, Lebanon |
|
|
|
My dissertation research project is divided into three parts: (1) Low –density lipoprotein receptor (LDLR) plays a pivotal role in cholesterol homeostasis. However the role of genetic variations (SNPs) in the 3’UTR of the LDLR in relation to plasma cholesterol has been largely understudied. Therefore my main research is to study the influence of these variations on gene expression and their association with the lipid profile. Also to study the interaction between these SNPs and Apolipoprotein E isoforms in determining the risk of atherosclerosis in humans. (2) To investigate a transcriptional enhancer activity in the first intron of the human low density lipoprotein receptor and to analyze for the presence of transcription factors. (3) To study the effect of SNPs in the promoter of the human LDLR on gene regulation. |
|
|
|
|